Regulatory function of T lymphocytes in the immune response to polyvinyl pyrrolidone. II. Characterization of the intrinsic suppressor and the induced suppressor.

Anti-PVP antibody² response is regulated by two categories of suppressor cells, the intrinsic suppressor and the induced suppressor. The intrinsic suppressor activity was dependent on the thymus-derived cells, which were relatively short-lived, insensitive to the treatment with a small dose of ATS (T₁), resistant to HC, and may be adherent to NW. On the other hand, precursor of the induced suppressor was long-lived, susceptible to ATS (T₂), and insensitive to HC. Induced suppressor itself was sensitive to HC, radiosensitive, and nonadherent to NW.These results suggest that the intrinsic suppressor and the antigen-induced suppressor belong to different subsets of T cells.