An improved method for butyrylcholinesterase phenotyping |
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| Authors: | G. Picheth C. Fadel-Picheth S. L. Primo-Parmo E. A. Chautard-Freire-Maia M. M. Vieira |
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| Affiliation: | (1) Department of Biochemistry, Federal University of Paraná, P.O. Box 19046, 81531-970 Curitiba, Paraná, Brazil;(2) Department of Genetics, Federal University of Paraná, Paraná, Brazil |
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| Abstract: | An improved method for the identification of butyrylcholinesterase phenotypes is proposed. It is based on modifications of a method that uses  -naphthyl acetate as substrate anddl-propranolol and Ro2-0683 as inhibitors. The proposed modifications make the method more rapid and increase the accuracy of the determinations of the phenotypes tested (BCHE U, BCHE UF, BCHE UA, BCHE AK, BCHE AF, and BCHE A). These modifications make the method even more adequate for population studies and clinical routine.We are grateful to the CNPq for research grants and scholarships.A preliminary report was presented at the Third International Meeting on Cholinesterases, France, May 12–16, 1990. |
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| Keywords: | serum cholinesterase butyrylcholinesterase serum cholinesterase phenotyping prolonged apnea |
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