真菌和氮素在食物链中与胃癌病因关系的探讨

作者等根据假设,即真菌与氮素通过食物链过程进入人体,由于真菌毒素或其代谢产物与胃内亚硝酸盐、胍类、胺类等合成致癌性亚硝基化合物,并在慢性胃炎的基础上逐渐发展为胃癌,在我国胃癌高,低发区进行了综合考察。本文报告考察结果,发现胃液内杂色曲霉(Aspergillus versicolor)检出率最高,高低发区对比差异显著(p<0.001)。此菌与胃液的pH值、酸度、NO_2~-含量、胃粘膜活检结果关系密切。已知杂色曲霉产的杂色曲霉素(sterigmatocystin)可诱发大鼠的腺胃癌,因此考虑此菌与人胃癌的发生可能有关,但是否为因果关系,尚需进一步实验研究。

INVESTIGATIONS ON THE PATHOGENESIS OF GASTRIC CARCINOMA IN RELATION TO FUNGUS AND NITROGEN IN THE FOOD-CHAIN

It is believed that fungus and nitrogen may be introduced into the body through the process of food-chain. A carcinogic nitrose-compound may be synthesized by mycotoxin or other metabolites together with nitrites, guanidines and amines present in the stomath. Consequently, gastric carcinoma may be developed gradually in cases of chronic gastritis. It is under such hypothesis that the authors undertook a comprechensive survey of gastric carcinoma in areas of high as well as low incidence in our country. The result of this survey revealed that a high discovery rate of Aspergillus versicolor was found in the gastric juice of an empty stomach. The difference between the high and low incidence areas is significant statistically (p<0.001). Aspergillus versicolor was found to be closely associated with the pH value and the levels of acidity and NO_2 in the gastric juice. It was also well correlated with the results of biospy of gastric mucosa. It is already known that the sterigmate-cystin produced by Aspergillus versicolor may induce gastric adenocarcinoma in laboratory animals. Therefore, the authors assume that this fungus may have a definite association with human gastric carcinoma. Further studies are necessary to elucidate its role in the pathogenesis of the disease.