Decrease in Spontaneous Motor Activity and in Brain Lipid Peroxidation in Manganese and Melatonin Treated Mice |
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Authors: | Enrique José Talavera José-Luis Arcaya Débora Giraldoth Jacqueline Suárez Ernesto Bonilla |
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Affiliation: | (1) Department of Neurobiology, Instituto de Investigaciones Biomedicas (INBIOMED). Fundacite-Zulia, Apartado postal 121, Maracaibo, Venezuela;(2) Instituto de Investigaciones Clínicas. Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela |
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Abstract: | In the present study, we have evaluated whether melatonin (MEL) modulates Mn-induced decrease in spontaneous motor activity (SMA) and lipid peroxidation, estimated as malondialdehyde (MDA) formation, in several brain regions. In mice treated with manganese a decrease in SMA after 2 weeks of treatment was observed. In the group treated with Mn+MEL a significant greater reduction in SMA was detected at 4 weeks. MDA levels were reduced in both MEL and Mn treated mice. In the animals treated with MEL + Mn a higher reduction in MDA levels was observed. These results suggest that MEL modulates the effect of Mn on SMA and brain lipid peroxidation. |
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Keywords: | Manganese melatonin malondialdehyde formation motor activity |
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