Molecular forms of the cholinesterases inside and outside muscle endplates |
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| Authors: | Jolanta Jedrzejczyk Israel Silman Joan M Lyles Eric A Barnard |
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| Institution: | (1) Department of Biochemistry, Imperial College, SW7 2AZ London, UK;(2) Present address: Department of Histology, Medical Academy, Warsaw, Poland;(3) Present address: Department of Neurobiology, Weizmann Institute of Science, Renovot, Israel |
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| Abstract: | Individual endplates were micro-dissected from chicken fast-twitch muscle, and the molecular forms of acetylcholinesterase and of pseudocholinesterase therein, identified by their sedimentation coefficients, were analysed directly. The forms actually present at the endplate, and those that are non-synaptic9 were established. This analysis was also extended to muscle of the chicken with inherited muscular dystrophy, showing altered distributions of these forms. |
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