The development of Staphylococcus-induced delayed hypersensitivity and antigen-non specific immunosuppression in a state of rest and during physical loading of varying intensities

Injection of live staphylococcal culture into mice induces the development of delayed hypersensitivity (DH) to microbial cells and suppresses the development of humoral immune response (HIR) to sheep red blood cells (SRBC). Physical loading of low intensity normalizes staphylococcus-suppressed HIR to SRBC, but produces no effect on staphylococcus-induced DH. Highly intensive physical loading suppresses the development of DH and enhances the suppressive effect of staphylococci on SRBC-induced HIR. The infection of animals with staphylococci induces the secretion of immunosuppressive factors by spleen cells. Physical loading of low intensity does not suppress the staphylococcus-induced secretion of suppressive factors by spleen cells, but induces the secretion of helper factors by these cells. Highly intensive physical loading enhances the secretion of immunosuppressive factors by spleen cells after infection with staphylococci.