Hematopoietic growth factor receptors

The formation of the cellular constituents of the blood is regulated by a series of endogenous polypeptides with largely paracrine function. A number of these hematopoietic growth factors (HGF's), which include colony stimulating factors, interleukins, and erythropoietin, have been purified to homogeneity and cloned, which in turn has led to extensive investigations of their biochemical properties and biological effects and functions. The HGF's act on target cells by binding to receptors. The kinetics and, to an even larger extent, dynamics of the factor/receptor associations display several intriguing characteristics, most of which are still poorly understood. Herein, the biochemical characteristics of HGF's receptors as well as the binding properties, post-receptor binding events and receptor modulation resulting from the association of HGF's and their target cells are reviewed.Abbreviations BMDM Bone Marrow-Derived Macrophages - CSF Colony-Stimulating Factor - cAMP cyclic 3,5-adenosine monophosphate - EPO Erythropoietin - fMLP formyl-methionylleucyl-phenylalanine - IFN Interferon - IL Interleukin - LPS Lipopolysaccharide - PEM Peritoneal E Exudate Macrophages - PKC Protein Kinase C - TNF Tumor Necrosis Factor - TPA 12-O-tetradecanoylphorbol-13-acetate - PtdIns(4,5)P₂ Phosphatidylinositol-4,5 bisphosphate