Adjuvant actions of polyclonal lymphocyte activators. V. Proliferation of macrophage colony-forming cells in the draining lymph node |
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| Authors: | T Yokochi I Nakashima N Kato T Miyadai K Yoshida Y Kimura |
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| Affiliation: | 1. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan;2. Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung, Taiwan;3. Department of Physics, Chemistry, and Biology, Linköping University, Sweden;4. Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan;5. Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan;6. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;7. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan |
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| Abstract: | We investigated the action of various polyclonal lymphocyte activators (PLA) on the proliferation of macrophage colony-forming cells in vivo at the local site. As PLA, Klebsiella pneumoniae 03 lipopolysaccharide (K03 LPS), Escherichia coli 0111 lipopolysaccharide (E. coli LPS), dextran sulfate (DS), concanavalin A (Con A), phytohemaggulutinin (PHA), polyadenylic-polyuridylic acid (poly(A:U], polyinosinic-polycytidylic acid (poly(I:C], and pokeweed mitogen (PWM) were used. All PLA tested acted to proliferate macrophage colony-forming cells in the draining lymph node at a late stage after subcutaneous injection. The order of strength of this action of PLA was K03 LPS greater than E. coli LPS greater than Con A greater than DS greater than PHA, PWM, poly(I:C), and poly(A:U), which corresponded to the order of strength of their adjuvant action in initiating helper-T-cell response to subcutaneous injection of aggregate-free bovine gamma-globulin. The detailed relationship between the proliferation of macrophage colony-forming cells and the adjuvant action of PLA is discussed. |
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