Sec-mediated secretion of bacteriocin enterocin P by Lactococcus lactis |
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| Authors: | Herranz Carmen Driessen Arnold J M |
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| Institution: | Department of Microbiology, Groningen Biomolecualr Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands. |
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| Abstract: | Most lactic acid bacterium bacteriocins utilize specific leader peptides and dedicated machineries for secretion. In contrast, the enterococcal bacteriocin enterocin P (EntP) contains a typical signal peptide that directs its secretion when heterologously expressed in Lactococcus lactis. Signal peptide mutations and the SecA inhibitor azide blocked secretion. These observations demonstrate that EntP is secreted by the Sec translocase. |
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