<Emphasis Type="Italic">Complement factor H</Emphasis> Y402H gene polymorphism and coronary heart disease susceptibility: a meta-analysis |
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Authors: | Hai-Feng Zhang Jing-Feng Wang Yan Wang Li-Guang Zhu Lei Lei |
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Institution: | (1) Department of Cardiology, The Second Affiliated Hospital, Sun Yat-sen University, 510120 Guangzhou, China;(2) Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, China; |
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Abstract: | The complement factor H (CFH) Y402H (T1277C) gene polymorphism has been reported to be associated with coronary heart disease (CHD), but results were
conflicting. To evaluate the role of the variant in CHD, we performed meta-analyses of all available data. Both electronic
and manual searches were performed, all relevant studies were identified. ORs with 95% confidential intervals (CI) under codominant
(CC versus TT, TC versus TT), dominant (CC + TC versus TT) and recessive (CC versus TT + TC) models were calculated. Publication
bias was addressed. Ten studies including 11 cohorts comprising of 29,764 participants were included. No association between
the CFH T1227C polymorphism and CHD could be found. (For overall analysis: dominant model, OR = 1.04, 95%CI: 0.97–1.11; recessive
model, OR = 1.04, 95%CI: 0.97–1.11; for Caucasian subgroup: OR = 1.08 95%CI: 0.92–1.27; recessive model, OR = 1.03, 95%CI:
0.96–1.11). Two studies reported positive results in separate population (Caucasian study: recessive model, OR = 0.51, 95%CI:
0.30–0.86; Asians study: dominant model, OR = 2.37, 95%CI: 1.13–4.96). Current evidence do not support the association between
the CFH T1277C polymorphism and CHD risk among common population. The association, which could be influenced by CHD onset age, CHD
risk factors status and genetics backgrounds, might be significant in some population. More studies on different CHD onset
ages and risk factor status should be encouraged. |
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