Hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol 7 alpha-hydroxylase activity in neonatal guinea pig. |
| |
| Authors: | J R Li M T Subbiah B A Kottke |
| |
| Affiliation: | 1. Cardiovascular Research Unit, Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901 USA;1. Lipoid Research Center, University of Cincinnati Medical Center, Cincinnati, Ohio 45229 USA |
| |
| Abstract: | Optimal assay conditions for hepatic HMG-CoA reducatase activity and cholesterol 7 alpha-hydroxylase activity in the guinea pig were determined. These two enzyme activities were studied in the liver of newborn guinea pigs during the first three postnatal weeks. Hepatic HMG-CoA reductase activity of neonatal guinea pigs was similar to that of adult animals. However, cholesterol 7 alpha-hydroxylase activity of newborns was about one-third of that in adult guinea pigs. This finding suggests that the system for bile acid synthesis in the neonatal guinea pigs is underdeveloped. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
