叶黄素酯对四氧嘧啶所致小鼠氧化损伤的保护性研究

目的研究万寿菊花中提取的叶黄素酯体内对四氧嘧啶所致的小鼠氧化损伤的影响。方法采用分光光度法测定模型组肝组织超氧化物歧化酶（SOD）、丙二醛（MDA）、过氧化氢酶（CAT）、谷脱甘肽（GSH）、血清中天门冬氨酶氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、肝糖原，脑、心脏、股四头肌SOD、MDA的活性。结果叶黄素酯可抑制由于氧化损伤所致的小鼠肝SOD、MDA、CAT、GSH和血清中AST、AIJT的异常升高；降低脑、心脏、股四头肌SOD、MDA水平；降低血糖，提高肝糖元水平。结论叶黄素可通过影响组织、血清中相关酶活性而对四氧嘧啶所致的小鼠氧化损伤有一定的保护作用。

The protective study of xangold on mice of oxidative damage by alloxan

Objective To study the protective of xangold from Tegeteserecta on mice of oxidative damage by alloxan. Methods The spectraphotometry was used to determine the activities of SOD,MDA,CAT and GSH in liver,the activities of AST and ALT in serum and the activities of SOD and MDA in brain, heart, musculus quadriceps femoris. Results Xangold could inhibit that the unusual rising of SOD, MDA, CAT, GSH level in the liver and AST,ALT in blood serum as well as SOD and MDA in brain ,heart, musculus quadriceps femoris of the mice. It also could reduce the blood sugar, raise the liver glycogen level. Conclusion Xangold has obvious protection to the mice oxidized damages by alloxan.