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Chiral carbocylic nucleosides: The synthesis and antiviral activity of 4′-hydroxy and 4′-fluorocarbocyclic - 2′- deoxyguanosines |
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| Authors: | Alan D Borthwick Keith Biggadike Ian L Paternoster Jonathan A V Coates and David J Knight |
| Institution: | Departments of Medicinal Chemistry 2 and Virology, Glaxo Group Research Greenford, Middlesex UB6 OHE UK |
| Abstract: | The chiral carbocyclic nucleosides 2 and 3 were prepared from aristeromycin. The 4′ -hydroxy compound 2 displays good antiviral activity against HSV-1 and HSV-2 with low toxicity. |
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