Green light for the secretory pathway |
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Authors: | H -H Gerdes and R Rudolf |
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Institution: | (1) Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Federal Republic of Germany |
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Abstract: | Summary Since the advent of green-fluorescent protein (GFP) technology there has been an explosion of interest in applying this molecule
to cell biology. This review summarizes new insights in secretory membrane traffic obtained by the use of GFP fusion proteins.
Transport steps between the endoplasmic reticulum and the Golgi apparatus, intra-Golgi traffic, and transport from the Golgi
to the plasma membrane are discussed. In addition, insights into the dynamics of the Golgi compartment in plant cells and
in mitotic mammalian cells have been included. We conclude that membrane traffic in the secretory pathway appears to be much
more dynamic and diverse than previously thought and that GFP promises to be a powerful means to unravel these complex processes. |
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Keywords: | Green-fluorescent protein Secretory pathway Secretory vesicle Endoplasmic reticulum Golgi apparatus Mitosis |
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