|
|||||
|
|
Lipoxin B, an enhancing factor of spontaneous platelet aggregation in whole blood |
|
| Authors: | A L Khshivo A S Nekrasov V Z Lankin A Iu Kholodov A M Vikhert G K Popov |
| Abstract: | The arachidonic acid metabolites, lipoxin B (5,14,15-trihydroxy-6,8,10,12-eicosatetraenoate) and 5,15-dihydroxy-eicosatetraenoate were shown to possess a marked effect on platelet aggregation and procoagulant activity. Lipoxin B increases and 5,15-dihydroxy-eicosatetraenoate decreases spontaneous platelet aggregation and procoagulant activity when added at various concentrations. The drugs tested were found to have no direct action on blood coagulation. |
| Keywords: | |