Proliferative senescence in hematopoietic stem cells during ex-vivo expansion |
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| Authors: | Piacibello Wanda Gammaitoni Loretta Pignochino Ymera |
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| Institution: | Laboratory of Medical Oncology, Department of Oncological Sciences, IRCC Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo, Turin, Italy. wanda.piacibello@ircc.it |
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| Abstract: | The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs. |
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