Function and cell distribution of KC-1, a novel natural killer cell-associated antigen |
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| Authors: | C Clayberger B Dyer B McIntyre T D Koller B Hardy P Parham L L Lanier A M Krensky |
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| Abstract: | Natural killer (NK) cell have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis. |
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