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Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury |
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| Authors: | Hiroaki Asai Hiroshi Fujiwara Sohei Kitazawa Naoto Kobayashi Toshiki Ochi Yukihiro Miyazaki Fumihiro Ochi Yoshiki Akatsuka Sachiko Okamoto Junichi Mineno Kiyotaka Kuzushima Hiroaki Ikeda Hiroshi Shiku Masaki Yasukawa |
| Institution: | 1. Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan 2. Department of Molecular Pathology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan 3. Medical Education Center, Ehime University Graduate School of Medicine, Toon, Ehime, Japan 4. Department of Hematology and Oncology, Fujita Health University, Toyoake, Aichi, Japan 5. Center for Cell and Gene Therapy, Takara Bio Inc, Otsu, Shiga, Japan 6. Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan 7. Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie, Japan |
| Abstract: | Because WT1 is expressed in leukemia cells, the development of cancer immunotherapy targeting WT1 has been an attractive translational research topic. However, concern of this therapy still remains, since WT1 is abundantly expressed in renal glomerular podocytes. In the present study, we clearly showed that WT1-specific cytotoxic T lymphocytes (CTLs) certainly exerted cytotoxicity against podocytes in vitro; however, they did not damage podocytes in vivo. This might be due to the anatomical localization of podocytes, being structurally separated from circulating CTLs in glomerular capillaries by an exceptionally thick basement membrane. |
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