Chemoenzymatic synthesis of functionalized cyclohexylglycines and alpha-methylcyclohexylglycines via Kazmaier-Claisen rearrangement |
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| Authors: | Hudlicky T Oppong K Duan C Stanton C Laufersweiler M J Natchus M G |
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| Affiliation: | Department of Chemistry, University of Florida, Gainesville 32611-7200, USA. |
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| Abstract: | The synthesis of homochiral functionalized cyclohexylglycines and alpha-methylcyclohexylglycines via chelated Kazmaier-Claisen rearrangement is described. These were shown to be potent scaffolds for the development of MMP inhibitors. |
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