Vibration stimulation during non-fatiguing tonic contraction induces outlasting neuroplastic effects |
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| Authors: | M Christova D Rafolt W Mayr B Wilfling E Gallasch |
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| Institution: | 1. Department of Physiology, Medical University of Graz, Harrachgasse 21/5, 8010 Graz, Austria;2. Center for Biomedical Engineering and Physics, Medical University Vienna, Austria;1. Brain and Mind Centre, Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia;2. Western Clinical School, University of Sydney, Sydney, NSW 2145, Australia;1. Department of Neurology and Neurosurgery, Division of Neurology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil;2. Department of Neurology and Neurosurgery, Division of Neurology, Section of Clinical Neurophysiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil;1. Department of Biomedical and Specialty Surgical Sciences, School of Medicine, University of Ferrara, via Fossato di Mortara 19, 44121 Ferrara, Italy;2. Department of Robotics, Brain and Cognitive Sciences, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy;1. Faculty of Sport Sciences, Waseda University, Saitama 359-1192, Japan;2. Department of Integrative Physiology, Kyorin University School of Medicine, Tokyo 181-8611, Japan;3. Department of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo, Tokyo 113-8549, Japan;1. Department of Mathematics, Technical University Munich, Munich, Germany;2. Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas;3. Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, Texas;4. Memorial Sloan Kettering Cancer Center, New York, New York |
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| Abstract: | The objective was to explore if vibration superposed to tonic contraction induces plastic changes in the contra- and ipsilateral motor cortex. Healthy subjects (n = 12) abducted the right index finger with a force 5% of maximal voluntary contraction (MVC) against the lever of a torque motor while a 60 Hz vibration stimulus of 10 min was delivered. Motor evoked potentials (MEPs) after single and paired-pulse transcranial magnetic stimulation (TMS) were recorded from the first dorsal interosseous muscle of right and left hand pre, during, post and 30 min post-stimulation. The TMS assessments were employed with tonic contraction alone (TONIC) and with superposed vibrostimulation (VIBRO), each for the ipsi- and contralateral cortex separately. In the contralateral cortex: resting motor threshold (rMT) decreased, MEP amplitudes increased, short-interval intracortical inhibition (SICI) reduced and intracortical facilitation (ICF) increased post VIBRO, while no changes occurred post TONIC. In the ipsilateral cortex: rMT decreased, MEP amplitude increased and SICI reduced during TONIC, while no changes occurred post TONIC, during and post VIBRO. Vibration superposed to tonic contraction, induces lasting (30 min) plastic changes, whereas contraction alone caused no outlasting effects. Mainly intrinsic intracortical mechanisms are involved because spinal adaptation could be excluded (F-wave assessments). These findings have a therapeutic potential in the functional recovery of motor deficits with robot-aided devices. |
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