The influence of enzymes on the estrogen receptors of human uterus and breast carcinoma |
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| Authors: | Roland Hähnel Ella Twaddle Laraine Brindle |
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| Affiliation: | University of Western Australia, Department of Obstetrics and Gynaecology, King Edward Memorial Hospital for Women, Subiaco 6008, Western Australia |
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| Abstract: | The influence of hydrolytic enzymes on the estrogen receptor and on the estradiol-receptor complex was studied. Proteolytic enzymes (trypsin, α-chymotrypsin, papain) phospholipases A and C, and β-glucuronidase reduced the subsequent in vitro binding of estradiol-17β by the receptor; they also released bound estradiol-17β from the estradiol-receptor complex. In addition, some glycosidases had an effect on the free receptor only. The results indicate that the estrogen receptor may contain phosphorus and carbohydrate moieties. |
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