Temporary inhibition by progesterone of sexual behavior in intact male mice

Administration of 0.50 mg or 1.00 mg progesterone (P) daily resulted in suppression of portions of the male sexual repertoire. Mice treated with 0.25 mg P daily behaved like control subjects. Sexual behavior of mice treated with the higher P doses resembled that of controls three weeks after cessation of P treatment. No lasting effects of P on total body weight or on weights of testes or seminal vesicles were detected.