Amino acid sequence restriction in relation to proteolysis |
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Authors: | Hans Jörnvall Bengt Persson |
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Affiliation: | 1. Department of Chemistry I, Karolinska Institutet, S-104 01, Stockholm 60, Sweden
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Abstract: | Distributions of amino acid residues in proteins show that proline is overrepresented in sequence positions following two basic residues ([Lys Arg]-[Lys Arg]), i.e. at sites similar to those susceptible to proteolytic cleavages of hormonal pro-forms. Conformational correlations further show that [Lys Arg]-[Lys Arg]-Pro sequences are often (8/11) not adjacent to elements of secondary structure, whereas the opposite applies to [Lys Arg]-[Lys Arg]-nonPro sequences (82/103 adjacent to elements of secondary structure). These distribution patterns from proteins in general also seem applicable in individual protein groups as demonstrated for some dehydrogenases. It appears possible that [Lys Arg]-[Lys Arg]-nonPro constitutes a restricted sequence in proteins, and that proline, in addition to elements of secondary structure, contributes a means of avoiding unacceptable proteolytic processings of proteins in general. |
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