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Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding
Authors:Holger Scheib  Iain McLay  Nicolas Guex  Jeff J Clare  Frank E Blaney  Tim J Dale  Simon N Tate  Graeme M Robertson
Institution:(1) SBC Lab AG, Seebüelstrasse 26, 8185 Winkel, Switzerland;(2) Department of Structural Biology and Bioinformatics, University of Geneva, 1, rue Michel-Servet, 1211 Geneva 4, Switzerland;(3) Swiss Institute of Bioinformatics, Centre Médicale Universitaire, 1, rue Michel-Servet, 1211 Geneva 4, Switzerland;(4) GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, SG1 2NY Stevenage, Hertfordshire, UK;(5) GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709, USA;(6) GlaxoSmithKline New Frontiers Science Park (North), Third Avenue, Harlow, Essex, CM19 5AW, UK;(7) sienabiotech SpA, via Fiorentina 1, 53100 Siena, Italy
Abstract:
Keywords:Voltage-gated sodium channels  Tetrodotoxin  Tetracaine  Protein structure modeling  Computational docking
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