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10-Hydroxycamptothecin produced by a new endophytic Xylaria sp., M20, from Camptotheca acuminata
Authors:Kaihui Liu  Xiaowei Ding  Baiwan Deng  Wenqiang Chen
Affiliation:(1) School of Biological Sciences and Engineering, Shaanxi University of Technology, 723001 Hanzhong, Shaanxi, People’s Republic of China
Abstract:A new 10-hydroxycamptothecin (HCPT)-producing fungus was isolated from Camptotheca acuminata. The strain was classified as a Xylaria sp. based on the internal transcribed spacer and 18S rDNA gene analysis. All elicitors tested, except methyl jasmonate, increased HCPT production in submerged culture. The maximum yield was 5.4 mg HCPT/l−1, when salicylic acid was added at 0.1 mM to the culture medium
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