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The interplay of structural information and functional studies in kinase drug design: insights from BCR-Abl
Authors:Michael J Eck  Paul W Manley
Affiliation:1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, United States;2. Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, United States;3. Novartis Institutes for Biomedical Research, WKL-136.4.86, Basel, CH-4002, Switzerland;1. Terry Fox Lab, British Columbia Cancer Agency, Vancouver, BC, Canada;2. The University of British Columbia, Vancouver, BC, Canada;1. Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, China;2. Division of Research on Virology and Immunology, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 102206, China;3. Liver Disease Institute, Shenzhen Third People’s Hospital, Shenzhen 518112, China;1. Department of Hematology and Hemotherapy, Hospital General Universitario Gregorio Marañón, Madrid, Spain;2. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain;3. Sequencing and Genotyping Research Support Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain;1. Department of Neurology, Vanderbilt University, 1161 21st Ave South, A-0118, Nashville, TN 37232, USA;2. UTHealth, The University of Texas School of Public Health, Austin Regional Campus, University of Texas Administration Building (UTA), 1616 Guadalupe Street, Suite 6.300, Austin, TX 78701, USA;3. Department of Neurology, University of California at San Francisco, 400 Parnassus Ave, Box 0348, San Francisco, CA 94143, USA;4. Department of Neurology, University of Colorado School of Medicine, Academic Office 1, Mail Stop B-185, 12631 East 17th Avenue, Aurora, CO 80045, USA;5. Department of Neurology, School of Medicine, University of California at San Francisco, 505 Parnassus Ave, Box 0114, San Francisco, CA 94143-0114, USA;6. Department of Neurological Sciences, University of Vermont College of Medicine, 1 South Prospect Street, Burlington, VT 05401, USA;7. Movement and Cognitive Disorders Center, Department of Neurology, Medical College of Georgia, Georgia Regents University, 1429 Harper Street, HF-1154, Augusta, GA 30912, USA;8. Barrow Neurological Institute, 240 W Thomas Road, Suite 301, Phoenix, AZ 85013, USA;9. Department of Neurology, University of Alabama at Birmingham and The Birmingham VA Medical Center, 1720 2nd Avenue South, Birmingham, AL 35294, USA;10. Department of Neurology, State University of New York, Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA;11. Department of Ophthalmology, State University of New York, Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA;12. Department of Neurology, LSU Health Sciences Center in Shreveport, 1501 King''s Highway, Shreveport, LA 71130, USA;13. Department of Neurology, Michigan State University, 804 Service Rd, Room A217, USA;1. Department of Pediatric Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;2. School of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;3. Bioscience Research Center, Senior Executive Asssociate Dean for Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA;4. Head of Hematology and Stem Cell Laboratory and Stem Cell Research Institute, School of Pharmacy; Federal University of Rio Grande do Sul, Porto Alegre, Brazil;3. From the Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219 and;4. the Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115
Abstract:
Keywords:
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