Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus) |
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| Authors: | Arumugham Balakumar Kim Hyo-Joong Prichard Mark N Kern Earl R Chu Chung K |
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| Affiliation: | University of Georgia College of Pharmacy, Athens, GA 30602, USA. |
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| Abstract: | An efficient method for the synthesis of 7-deazaneplanocin A (2) has been accomplished by the condensation of cyclopentenol 3 with 6-chloro-7-deazapurine followed by subsequent functional group manipulations. The synthesized 7-deazaneplanocin A (2) exhibited potent antiviral activity against cowpox and vaccinia viruses without cytotoxicity in HFF cells. |
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