Modelling biochemical networks with intrinsic time delays: a hybrid semi-parametric approach |
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| Authors: | Moritz von Stosch Joana Peres Sebastião Feyo de Azevedo Rui Oliveira |
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| Affiliation: | 1.Departamento de Engenharia Química,LEPAE, Faculdade de Engenharia, Universidade do Porto,Porto,Portugal;2.Departamento de Quimica,REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa,Caparica,Portugal |
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| Abstract: | Background This paper presents a method for modelling dynamical biochemical networks with intrinsic time delays. Since the fundamental mechanisms leading to such delays are many times unknown, non conventional modelling approaches become necessary. Herein, a hybrid semi-parametric identification methodology is proposed in which discrete time series are incorporated into fundamental material balance models. This integration results in hybrid delay differential equations which can be applied to identify unknown cellular dynamics. |
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