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Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats |
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| Authors: | David HT Yen Lih-Chi Chen Yuh-Chiang Shen Ying-Chen Chiu I-Chun Ho Ya-Jou Lou I-Chin Chen Jiin-Cherng Yen |
| Institution: | (1) Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan;(2) Emergency Department, Taipei Veterans General Hospital, Taipei, Taiwan;(3) Department of Pharmacy, Taipei City Hospital, Taipei, Taiwan;(4) National Research Institute of Chinese Medicine, Taipei, Taiwan;(5) Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan |
| Abstract: | BackgroundAdrenomedullin (ADM) exerts its biological functions through the receptor-mediated enzymatic mechanisms that involve protein kinase A (PKA), or neuronal nitric oxide synthase (nNOS). We previously demonstrated that the receptor-mediated cAMP/PKA pathway involves in ADM-enhanced baroreceptor reflex (BRR) response. It remains unclear whether ADM may enhance BRR response via activation of nNOS-dependent mechanism in the nucleus tractus solitarii (NTS). |
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