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The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein |
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| Authors: | Seo Hyun Lee Sungchan Cho M Sun Kim Kwangman Choi Jae Youl Cho Ho-Shin Gwak Youn-Jae Kim Heon Yoo Seung-Hoon Lee Jong Bae Park Jong Heon Kim |
| Institution: | 1. Cancer Cell and Molecular Biology Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi 410-769, Republic of Korea;2. Specific Organs Cancer Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi 410-769, Republic of Korea;3. Department of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Gyeonggi 410-769, Republic of Korea;4. Targeted Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang 685-1, Republic of Korea;5. Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea |
| Abstract: | |
| Keywords: | CIP calf intestinal alkaline phosphatase DMEM Dulbecco's modified Eagle medium DMSO dimethyl sulfoxide DPBS Dulbecco's phosphate-buffered saline DTT dithiothreitol EDTA ethylenediaminetetraacetic acid FBS fetal bovine serum GAPDH glyceraldehyde-3 phosphate dehydrogenase GST glutathione S-transferase HMGA2 high mobility group AT-hook 2 miRNA microRNA NB Northern blot PCR polymerase chain reaction miRNP microRNA ribonucleoprotein nt nucleotides PMSF phenylmethylsulphonylfluoride PTM posttranslational modification RING really interesting new gene RNP ribonucleoprotein SD standard deviation siRNA small interfering RNA TRIM71 tripartite motif protein 71 3&prime UTR 3&prime untranslated region WB Western blot |
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