| Institution: | 1. Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy;2. Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy;3. Human Genetics Foundation (HuGeF), 10126 Torino, Italy |
| Abstract: | The tissue-specific gene expression changes mediated by the hypoxia inducible factors (HIFs) allow the adaptation of cells to low oxygen tension and control several processes including erythropoiesis, angiogenesis and vasculogenesis. The Feline Leukemia Virus, subgroup C, Receptor 1 (Flvcr1) gene encodes for two isoforms, Flvcr1a and 1b, involved in the export of heme out of the cell and of mitochondria respectively. Studies in mouse models demonstrated a crucial role of Flvcr1 isoforms in erythropoiesis and during embryo development. |
