Hepcidin, an antimicrobial peptide is downregulated in ceruloplasmin-deficient mice |
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Authors: | Guo Pei Cui Rui Chang Yan-Zhong Wu Wen-Shuang Qian Zhong-Ming Yoshida Kunihiro Qiao Ya-Tiao Takeda Shin'ichi Duan Xiang-Lin |
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Affiliation: | Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050016, Hebei Province, People's Republic of China. |
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Abstract: | Hepcidin, a principle regulator of iron metabolism, is synthesized by the liver. Contradictory results have been reported on the regulation of hepcidin expression in response to serum transferrin saturation and liver iron content. In the present study, we explore the expression of murine hepcidin mRNA and further analyze the relationship between liver hepcidin mRNA expression, liver iron stores, and serum iron level utilizing ceruloplasmin gene knockout mice. We find that hepcidin expression correlates significantly with serum transferrin saturation, whereas there is a negative correlation of hepcidin expression with liver tissue iron level. |
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