Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives |
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Authors: | Rawal Ravindra K Katti S B Kaushik-Basu Neerja Arora Payal Pan Zhenhua |
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Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil, PO Box No. 173, Lucknow, UP 226 001, India. |
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Abstract: | Hepatitis C virus (HCV) NS5B RNA polymerase is crucial for replicating the HCV RNA genome and is an attractive target for developing anti-HCV drugs. A novel series of 2,3-diaryl-1,3-thiazolidin-4-one derivatives were evaluated for their ability to inhibit HCV NS5B. Of this series, compounds 4c, 5b, 5c and 6 emerged as more potent, displaying over 95% inhibition of NS5B RNA polymerase activity in vitro. The two most active compounds 4c and 5c exhibited an IC(50) of 31.9 microM and 32.2 microM, respectively, against HCV NS5B. |
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