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The discovery of equipotent PPARalpha/gamma dual activators |
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| Authors: | Martres Paul Faucher Nicolas Laroze Alain Pineau Olivier Fouchet Marie Helene Potvain Florent Grillot Didier Beneton Veronique |
| Affiliation: | Department of Medicinal Chemistry, Laboratoire GlaxoSmithKline, Centre de Recherches, 25-27 avenue du Québec, 91951 Les Ulis, France. paul.martres@gsk.com |
| Abstract: | We report the design and synthesis of equipotent PPARalpha/gamma dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented. |
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