1H, 15N and 13C backbone chemical shift assignment of the titin A67-A68 domain tandem |
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Authors: | András Czajlik Gary S Thompson Ghulam N Khan Arnout P Kalverda Steve W Homans John Trinick |
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Institution: | (1) Institute for Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK; |
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Abstract: | Single molecules of the giant protein titin extend across half of the muscle sarcomere, from the Z-line to the M-line, and
have roles in muscle assembly and elasticity. In the A-band titin is attached to thick filaments and here the domain arrangement
occurs in regular patterns of eleven called the large super-repeat. The large super-repeat itself occurs eleven times and
forms nearly half the titin molecule. Interactions of the large super-repeats with myosin are consistent with a role in thick
filament assembly. Here we report backbone assignments of the titin A67-A68 domain tandem (Fn-Ig) from the third super-repeat
(A65-A75) completed using triple resonance NMR experiments. |
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