Long-lasting blockade of P2-receptors of the urinary bladder in vivo following photolysis of arylazido aminopropionyl ATP, a photoaffinity label |
| |
Authors: | R J Theobald V Hoffman |
| |
Institution: | 1. Kirksville College of Osteopathic Medicine Department of Pharmacology 800 West Jefferson Kirksville, Missouri 63501, USA;2. Science Division Northeast Missouri State University Kirksville, Missouri 63501, USA |
| |
Abstract: | In the present study the possibility of provoking an irreversible blockade of P2-receptors in vivo by photolyzing ANAPP3 was investigated. ANAPP3 administered as an intraarterial infusion produced a short-lived blockade of P2-receptor mediated contractions of cat urinary bladders in situ. However, irradiation of the bladders with visible light during the infusion of ANAPP3 resulted in a blockade of the response for at least 120 minutes. Thus, photoactivation of ANAPP3 in vivo produced an essentially irreversible blockade of P2-purinergic receptors. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|