Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes |
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Authors: | Khanum Shaukath Ara Murari Satish Kumar Vishwanth Bannikuppe Sannanaik Shashikanth Sheena |
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Affiliation: | Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India. |
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Abstract: | Benzoylation of (hydroxy phenyl) phenyl methanone 2a-g to benzoyl phenyl benzoates 4a-g, a benzophenone analogue, was achieved in good yield. All the newly synthesized compounds were evaluated for their phospholipase A2 [E.C. 3.1.1.4] and hyaluronidase [E.C. 3.2.1.35] enzyme inhibitory activity in snake venom as source and their structure-activity relationship with respect to different groups is reported for the first time. The in vitro PLA2 enzyme inhibitory activity and in vivo anti-inflammatory activity studies of benzoyl phenyl benzoates are illustrated. |
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