The modeled structure of the RNA dependent RNA polymerase of GBV-C Virus suggests a role for motif E in <Emphasis Type="Italic">Flaviviridae</Emphasis> RNA polymerases |
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Authors: | Fran?ois?Ferron Cécile?Bussetta Hélène?Dutartre Email author" target="_blank">Bruno?CanardEmail author |
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Institution: | 1.Architecture et Fonction des Macromolécules Biologiques,UMR 6098 CNRS et Université Aix-Marseille I et II, ESIL, Campus de Luminy,Marseille Cedex 09,France;2.Boston Biomedical Research Institute,Watertown,USA |
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Abstract: | Background The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the
replication process, and thus is a validated target for antiviral drugs. Despite the increasing structural and enzymatic characterization
of viral RdRps, detailed molecular replication mechanisms remain unclear. The hepatitis C virus (HCV) is a major human pathogen
difficult to study in cultured cells. The bovine viral diarrhea virus (BVDV) is often used as a surrogate model to screen
antiviral drugs against HCV. The structure of BVDV RdRp has been recently published. It presents several differences relative
to HCV RdRp. These differences raise questions about the relevance of BVDV as a surrogate model, and cast novel interest on
the "GB" virus C (GBV-C). Indeed, GBV-C is genetically closer to HCV than BVDV, and can lead to productive infection of cultured
cells. There is no structural data for the GBV-C RdRp yet. |
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