PER3 VNTR circadian gene is associated with arterial stiffness variable in healthy subjects |
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| Authors: | S. N. Kolomeichuk V. V. Ilyukha V. A. Korneva T. Yu. Kuznetsova |
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| Affiliation: | 1. Institute of Biology, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Russia;2. Department of Faculty Therapy, Phthisiology, Infectious Diseases and Epidemiology, Petrozavodsk State University, Petrozavodsk, Russia |
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| Abstract: | It is established that arterial stiffness is one of the risk factors for cardiovascular morbidity and mortality. We tested the hypothesis that alterations in genetic structure of circadian gene PER3 could affect hemodynamic parameters. Previously, we showed that CLOCK gene variants had a pronounced effect on arterial vasculature. Augmentation index (AIx) was significantly higher in the PER35/5 group than in the PER34/4 and PER34/5 groups, whereas other hemodynamic parameters, such as RWTT, PWV, and ASI, were not significantly different. |
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| Keywords: | Arterial stiffness normotensives PER3 circadian genes SNP |
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