Waterborne copper disrupts circadian rhythm in red seabream (Pagrus major) |
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Authors: | Tae Hwan Kim Ji Yong Choi In-Seok Park |
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Affiliation: | Division of Marine BioScience, Korea Maritime and Ocean University, Busan, Republic of Korea |
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Abstract: | We investigated the effect of copper (Cu) on circadian rhythms in red seabream, Pagrus major, under various concentrations of Cu (10, 20, 30 and 40 μg/L). To examine variability in circadian rhythms, we measured changes in the period 2 (Per2), cryptochrome 1 (Cry1), serotonin and arylalkylamine N-acetyltransferase (AANAT2) proteins. We found that circadian rhythm-related plasma proteins were significantly lower in a high-Cu environment (30–40 μg/L) than in low-Cu concentration (0, 10, or 20 μg/L). Our results indicate that environmental Cu at concentrations greater than 30 μg/L can have deleterious effects on fish circadian rhythms. |
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Keywords: | Copper circadian rhythms clock proteins Pagrus major |
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