MicroRNAs-29a/b/c regulate early growth response 2 (Egr2) by mPer1 |
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Authors: | Junjie Ying Yuhui Wang Wang Hou Xiaoxue Li Zhou Jiang Yanyou Liu |
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Institution: | Health Ministry Key Laboratory of Chronobiology, College of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu, P.R. China |
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Abstract: | The circadian rhythm is one of the basic systems in an organism. It helps the organism maintain harmony with the daily changes of the external environment to ensure proper physiological activities. Previous studies from our laboratory have indicated that the miR-29a/b/c can bind to the circadian clock gene hPer1 at the 3 ′UTR region and regulate its mRNA and protein expression, affecting various organismal physiological processes. Meanwhile, it has been reported that the circadian gene Per plays a role in the regulation of the early growth response gene Egr2, which plays an important role during midbrain development. Here, we confirmed that miR-29a/b/c regulates Egr2 function through mPer1 binding, which elucidates a novel connection between mPer1 and Egr2. |
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Keywords: | Circadian rhythm miR-29a/b/c NIH3T3 mPer1 Egr2 cell proliferation |
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