Stimulation of insulin release by L-glutamine |
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| Authors: | Abdullah Sener Willy J. Malaisse |
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| Affiliation: | (1) Laboratory of Experimental Medicine, Brussels University, Brussels, Belgium |
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| Abstract: | Summary Under normal environmental conditions, L-glutamine is well oxidized but fails to stimulate insulin release in rat pancreatic islets. However, a marked stimulation of insulin release by L-glutamine, without alteration in its oxidation rate, occurs when the intracellular pH of the islet cells is decreased and/or when theophylline is added to the incubation medium. |
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