Antimicrobial efficacy of quaternary bisammonium salts and the effect of their sub-MICs onPseudomonas aeruginosa virulence factors |
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Authors: | A Ho?tacká V Majtán D Hybenová |
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Institution: | (1) Institute of Preventive and Clinical Medicine, 833 01 Bratislava, Slovak Republic |
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Abstract: | Antipseudomonadal activity of homologous series of six quaternary bisammonium salts (QBAS) (4,7-dioxo-3,8-dioxadekan-1,1-bis(alkyldimethyldiammonium
dibromide)] as well as the effect of their subinhibitory concentrations (sub-MICs) onPseudomonas aeruginosa virulence factors was studied. Antibacterial activity of QBAS increased up to a certain length of the chain and then decreased
with further elongation. All the tested sub-MICs of QBAS caused a significant suppression of phospholipase C activity (to
0–41%). Elastase and proteinase activity were less efficiently reduced. A more effective decrease of these activities was
only found after treatment with one-fourth of the MICs of the tested substances. QBAS caused only an erratic decrease of alginate
production. |
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