Experimental candidal mastitis in goats: Clinical,haematological, biochemical and sequential pathological studies |
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Authors: | Singh Pritpal Sood N Gupta PP Jand SK Banga HS |
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Institution: | (1) Department of Veterinary Pathology, Punjab Agricultural University, Ludhiana, India |
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Abstract: | The present study, first of its kind, was conducted with the objectives to understand hitherto little known aspects of candidal
mastitis, like its sequential pathology, pathogenesis and clinico-biochemical changes. For this purpose, unilateral intramammary
inoculation of 10 goats with Candida albicans (1.2 × 107 yeast cells) resulted in the development of mastitis, with gross and microscopic lesions being restricted to the infected
udder halves only and without dissemination of infection to the opposite uninfected udder halves as well as other organs of
the body. The experiment was continued for 40 days and after infection, there was sharp fall in milk yield and Candida albicans
was directly demonstrated in the milk and re-isolated from the milk and udder tissues up to 30th day after inoculation. An
increase in total immunoglobulins in the milk and plasma along with increase in total plasma proteins were also observed.
Haematology revealed leukocytosis and neutrophilia. Microscopically, there was acute purulent mastitis, which later became
chronic, nonpurulent and interstitial with formation of granulomas. It was concluded that Candida albicans was highly pathogenic
to the lactating goat mammary gland even without immunosuppression or antibiotic treatment, resulting in severe irreversible
tissue damage and nearly complete agalactia.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | Candida albicans goats mastitis pathology experimental pathogenesis haematology biochemical changes |
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