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Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir) |
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| Authors: | Sham H L Betebenner D A Herrin T Kumar G Saldivar A Vasavanonda S Molla A Kempf D J Plattner J J Norbeck D W |
| Institution: | Pharmaceutical Discovery, D47B, Building AP-10, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. hing.l.sham@abbott.com |
| Abstract: | The HIV protease inhibitor ABT-378 (Lopinavir) is metabolized rapidly and extensively by CYP-3A4 catalyzed oxidation. Three of the major metabolites identified were synthesized and their antiviral (HIV) activities determined. |
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