Difference in the number of insulin binding sites between cortisol-sensitive and cortisol-resistant lymphoma P1798 cells.

Cortisol-sensitive and cortisol-resistant lymphoma P1798 cells specifically bind 25I]insulin. Resistant lymphocytes bind 40% less insulin than sensitive cells. These results suggest that insulin (or insulin-like substances) may play a role in growth regulation and/or response of this tumor to glucocorticoid therapy.