快速减压对豚鼠外周微循环和大脑血流量的影响

目的：探讨动物处于减压病（ＤＣＳ）临界发病状态时微及其血流动力作用的改变。方法：采用小型化激光微综在数测量仪及ＬＤＦ－３微区血流量仪，以检测动物高压暴露前及快速减压后微循环和血流动力作用的改变。结果：快速减压后动物微血管明显收缩；毛细血管开放数量减少；微循环中可见气泡并有血栓形成；白细胞、血小板与血管内皮粘附；血流中有料多白色微小血栓；细动脉血流速度平均比正常状态减慢０．９ｍｍ／ｓ，细静脉流速减慢

EFFECTS OF FAST DECOMPRESSION ON PERIPHERAL MICROCIRCULATION AND CEREBRAL VOLUME OF BLOOD FLOW IN GUINEA PIG

Aim:Changes of microcirculation and hemodynamics were probed during critical decompression sickness (DCS) in animals. Methods: Small laser microcirculatory synthetical parameter meter and LDF-3 laser doppler flowmeter were used in the experiment, the changes of microcirculation and hemodynamics were measured before hyperbaric exposure and after fast decompression in animals. Results: After fast decompression in animals, microvessels constracted, open number of capillary reduced, air bubbles occurred and thrombi formed in microcirculation, leukocytes and platelets adhered to endothelial cells. There were many white microthrombi in the blood now. Average blood flow rate of arteriole decreased 0.9 mm/s, venulae decreased 0.7 mm/s, cerebral volume of blood fiow droped 50% or over as compared with the control group( P <0.01). Conclution: After fast decompression, inert gas dissolved in body could not be inability safety desaturation, result in a powerfull stress reaction and injury in the body. Microcircutory homodynmics disorder, ischemia and hypoxia occurred in tissue and air bubbles formed.