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Advances in the generation of bioengineered bile ducts |
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| Authors: | Alexander W. Justin Kourosh Saeb-Parsy Athina E. Markaki Ludovic Vallier Fotios Sampaziotis |
| Affiliation: | 1. Department of Engineering, University of Cambridge, Cambridge, UK;2. Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK;3. Wellcome Trust–Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK;4. Wellcome Trust Sanger Institute, Hinxton, UK;5. Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK |
| Abstract: | The generation of bioengineered biliary tissue could contribute to the management of some of the most impactful cholangiopathies associated with liver transplantation, such as biliary atresia or ischemic cholangiopathy. Recent advances in tissue engineering and in vitro cholangiocyte culture have made the achievement of this goal possible. Here we provide an overview of these developments and review the progress towards the generation and transplantation of bioengineered bile ducts. This article is part of a Special Issue entitled: Cholangiocytes in Health and Diseaseedited by Jesus Banales, Marco Marzioni and Peter Jansen. |
| Keywords: | Bile duct Tissue engineering Bioengineering Cholangiopathy |
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