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DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells |
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| Authors: | Mikhail Baryshev Inna Inashkina Kristine Salmina Anda Huna Thomas R Jackson |
| Institution: | 1. August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Ratsupites 5, LV-1067 Riga, Latvia;2. Latvian Biomedical Research &3. Study Centre, Ratsupites 1, Riga LV-1067, Latvia;4. Faculty Institute for Cancer Sciences, University of Manchester, Manchester, M13 9WL, UK |
| Abstract: | |
| Keywords: | embryonal carcinoma wt TP53 DNA damage Oct4A enhancer methylation alternative splicing cell senescence transient pluripotency suppression |