Intercellular mitochondria trafficking highlighting the dual role of mesenchymal stem cells as both sensors and rescuers of tissue injury |
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| Authors: | Anne-Marie Rodriguez Jean Nakhle Emmanuel Griessinger Marie-Luce Vignais |
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| Affiliation: | 1. Institut Mondor de Recherche Biomédicale, INSERM U955, Université Paris-Est, UMR-S955, UPEC, Créteil, Franceanne-marie.rodriguez@inserm.fr;3. Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS, Montpellier, France;4. Université C?te d'Azur, INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M). Team 4 Leukemia: Molecular addictions, Resistances and Leukemic Stem Cells;5. Institute for Regenerative Medicine and Biotherapy, Université de Montpellier, INSERM, France |
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| Abstract: | Mitochondria are crucial organelles that not only regulate the energy metabolism, but also the survival and fate of eukaryotic cells. Mitochondria were recently discovered to be able to translocate from one cell to the other. This phenomenon was observed in vitro and in vivo, both in physiological and pathophysiological conditions including tissue injury and cancer. Mitochondria trafficking was found to exert prominent biological functions. In particular, several studies pointed out that this process governs some of the therapeutic effects of mesenchymal stem cells (MSCs). In this review, we give an overview of the current knowledge on MSC-dependent intercellular mitochondria trafficking and further discuss the recent findings on the intercellular mitochondria transfer between differentiated and mesenchymal stem cells, their biological significance and the mechanisms underlying this process. |
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| Keywords: | Stem cells mitochondria cell-cell interactions |
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